• Toxicology

EpiDerm

MatTek’s patented EpiDerm system is a leading in vitro testing technology for dermal toxicologists and formulation scientists. With multiple ECVAM validations and OECD accepted test guidelines, EpiDerm is a proven in vitro system for chemical, pharmaceutical and skin care product testing. 


Applications:

- Skin Irritation (OECD TG 439)

- Dermal Genotoxicity

- Skin Corrosion (OECD TG 431)

- Phototoxicity

EpiOcular 

EpiOcular’s strong correlation to historical in vivo data sets and exceptional reproducibility make it an ideal model for ocular safety testing of raw ingredients and final formulations. EpiOcular has been used for many years as a non- animal, in vitro alternative to determine Draize scores (for water soluble test articles) and to assess the mildness / ultra-mildness (sub-Draize) of materials contacting the eyes. 


Applications:

- Eye Irritation Test (OECD 492) 

- Mtt ET-50 (Dilution)

- Sub-Draize Ultra Mildness 

- MTT ET-50 (Neat)

EpiAirway And EpiAlveolar

MatTek’s EpiAirway is advancing in vitro respiratory research worldwide. Allowing for physiological exposures to pathogens, chemicals or therapeutics, EpiAirway’s 

human-relevant biological responses are changing the way scientists research respiratory diseases and drug development. 


Applications:

Viral Infection 

Inhalation Toxicology

EpiOral And EpiGingival

Various industrial and toxicology laboratories are actively seeking alternatives to expensive clinical or whole animal testing. Oral care, personal care, and pharmaceutical companies have initiated in vitro toxicology testing to evaluate their raw materials and final product formulations. 

MatTek’s oral tissue models provide a highly reproducible, physiological means to screen newly developed oral care products.


Applications:

Gingival Irritation

Mucosal Irritation

EpiIntestinal

MatTek’s 3D tissue model of the human small intestine is our latest innovation advancing in vitro GI research worldwide. Allowing for physiological exposures and human-relevant endpoints, EpiIntestinal is being incorporated into pharmaceutical development programs across the globe. 

A human 3D in vitro small intestinal tissue model with epithelial polarity to evaluate toxicity, metabolism, drug absorption and compound efficacy. MatTek’s latest novel innovation to help redefine preclinical testing. 


Applications:

- GI Toxicity

- GI Infection

EpiVaginal

EpiVaginal provides an in vitro research tool for feminine product safety testing, drug development and for the study of HIV-1 and other sexually transmitted diseases. Human-like 3D tissue structure and cellular physiology make it ideal for toxicology, drug delivery and formulation efficacy testing.. 


Applications:

- Microbicide Testing 

- Inflammation